Amisquioumisca Lake is a freshwater body consisting of a major body of water in the Nipukatasi River, on the South Hydrographic Slope of the Broadback River, in the Municipality of Eeyou Istchee Baie-James (municipality), in the administrative region of Nord-du-Québec, in Quebec, in Canada.

The hydrographic slope of Amisquioumisca Lake is accessible via the James Bay Highway (North-South direction) from Matagami, passing on the west side of the lake.

The surface of Amisquioumisca Lake is usually frozen from early November to mid-May, however, safe ice circulation is generally from mid-November to mid-April.

While on the northwest side, the major body of water is Evans Lake.

The Amisquioumisca Lake is fed by several riparian creeks and especially the Nipukatasi River (coming from the North).