[1][2][3] The club is located close to the village of San Rafael on the highway between Sant Antoni de Portmany and Ibiza Town.

In May 1976, the widow signed a five-year lease on the house to Antonio Escohotado, a Madrid-born philosopher who had arrived on the island five years earlier to start a new life.

Unexpected closings alternated with summers with capacity crowds in competition with the other discothèques, such as Ku (now Privilege Ibiza), Pacha, Glory's, and Lola's.

In the 1980s, Prontxio Izaguirre took over Amnesia, changing its theme to dance music, a mix between pop and funk, and hip hop.

In the mid-1990s, Ezna Sands brought UK promoters and labels, including Joseph Mullen, onto the Balearic Island and into Amnesia.

Over the years, the club hosted DJs and live performers such as Calvin Harris, Swedish House Mafia, Debbie McGee, Alesso, Marshmello, Dimitri Vegas & Like Mike, Steve Aoki, Eric Prydz, Sigala, Sigma, Jonas Blue, Sonny Fodera, Gorgon City, Faithless, Chase & Status, Pete Tong, Fatboy Slim, Duke Dumont, Danny Howard, Philip George, Regard and DJ Fresh.