His songs "Silence" (featuring Khalid), "Wolves" (with Selena Gomez), "Friends" (with Anne-Marie), "Happier" (with Bastille), and "Alone" have each received multi-platinum certifications in several countries, and peaked within the top 40 of the Billboard Hot 100.

Released in May of that year by indie label Monstercat, his single "Alone", peaked at number 28 on the US Billboard Hot 100 and received quintuple platinum certification by the Recording Industry Association of America (RIAA).

"Happier", a collaboration with British band Bastille, was released that August and became his highest-charting song on the Billboard Hot 100, peaking at number two.

[5] In 2020, he and American rapper Juice Wrld released "Come & Go", from the latter's posthumous album Legends Never Die; the song matched "Happier" on the Billboard Hot 100.

[10] One single was released from the album, titled "Keep It Mello", featuring Mexican rapper Omar Linx, and was certified gold by the Recording Industry Association of America (RIAA).

[11][12] It was later regarded as a publicity stunt by fans and the media due to their conflicting tour dates and a photo of "the two helmeted DJs hanging out together pre-show".

[13][14] He announced the Ritual Tour on Twitter, in which he performed in several countries including the United States, China, South Korea, India and Paraguay from late September until early January of the following year.

[15][e] The tour was accompanied with his debut on dubstep musician Skrillex's Owsla label, with a single titled "Ritual", in which vocalist Wrabel was featured.

[d] Soon after, Marshmello launched his own record label named Joytime Collective and recruited fellow DJ and producer Slushii as the first signee on its roster.

[17] Marshmello collaborated with Ookay to release the single "Chasing Colors", featuring vocals by American singer Noah Cyrus.

[21][d] Months later, Marshmello announced upcoming collaborations with American hip hop recording artist Blackbear[22] and Demi Lovato.

"[24] His next single, announced on Twitter, was a collaboration with American R&B singer Khalid titled "Silence", which was released on August 11, 2017, via RCA Records.

[a] Later in the year, he released his collaboration with American singer Selena Gomez, the single "Wolves" which became a commercial success,[26] having reached the top 10 in more than 20 countries.

It was also his highest-charting Billboard Hot 100 song in 2017, having peaked in the Top 50 of over 50 countries and sold over 2.5 million copies of certified units.

[a] Succeeding "Wolves", the single "You & Me" was released through Joytime Collective,[27] accompanied by an animated music video which was produced and directed by Toon53.

On June 19, Marshmello announced on Twitter his second studio album titled Joytime II, which would be musically similar to its predecessor.

[34] Rolling Stone described it as monotonous and Marshmello's decision to not feature guests as disappointing, stating "every song sounds like it has already been pre-leased for use by energy-drink companies or extreme-sports squads."

[36] Two singles were released off the album in June, titled "Tell Me" and "Check This Out",[33][c] the latter of which receiving an official music video published several months later.

[44] In June 2019, he released "Rescue Me", a collaboration with American rock band A Day to Remember as the first single from his third album, Joytime III.

[47] In July 2020, Marshmello appeared on rapper Juice WRLD's posthumous album Legends Never Die, on the tracks "Come & Go" and "Hate the Other Side", which reached numbers two and ten on the Billboard Hot 100, respectively, with the former matching "Happier" as his highest-charting song.

[62] Marshmello, together with Fortnite player Tyler "Ninja" Blevins, have won prize money of $1 million from Epic Games's E3 Celebrity Pro Am charity tournament,[63] half of which was donated to KIND (Kids in Need of Defense), an organization providing legal counsel to refugees and immigrant children.

[64] With the single "Happier" and its pet-dog-themed video, he supported the #FindYourFido campaign by American Society for the Prevention of Cruelty to Animals (ASPCA) in October 2018, also recognized as "Adopt a Shelter Dog" month.