In the 1980s, Cook was the bassist for the Hull-based indie rock band the Housemartins, who achieved a UK number-one single with their a cappella cover of "Caravan of Love".

After the Housemartins split up, Cook formed the electronic band Beats International in Brighton, who produced the number-one single "Dub Be Good to Me".

Follow-up albums You've Come a Long Way, Baby, Halfway Between the Gutter and the Stars, and Palookaville, as well as singles such as "The Rockafeller Skank", "Praise You", "Right Here, Right Now", "Weapon of Choice" and "Wonderful Night", achieved commercial and critical success.

In 2008, Cook formed the Brighton Port Authority, a collaborative effort with a number of other established artists including David Byrne.

Their original bassist, Ted Key, left on the eve of their first national tour, so Cook agreed to move to Hull to join them.

Heaton and the drummer, Dave Hemingway, went on to form the Beautiful South, while Cook moved back to Brighton to pursue his interest in the style of music he preferred.

[citation needed] Cook achieved his first solo hit in 1989, "Blame It on the Bassline", featuring future Beats International member MC Wildski.

[13] Cook formed Beats International, a loose confederation of studio musicians including the vocalists Lindy Layton and Lester Noel, the rappers D.J.

Their first album, Let Them Eat Bingo, included the number-one single "Dub Be Good to Me", which caused a legal dispute over allegations of copyright infringement through the liberal use of unauthorised samples: the bassline was taken from the Clash's "The Guns of Brixton" and the chorus was an interpolation of the S.O.S.

[citation needed] Cook enlisted help from producer friends Tim Jeffery and JC Reid to create a house music album as Pizzaman.

[citation needed] Cook also formed the group The Mighty Dub Katz with Gareth Hansome (aka GMoney), his former flatmate.

[22] The album also included "Sunset (Bird of Prey)," whose socially significant video sampled the 1964 "Daisy Girl" campaign ad.

The recordings took place at Cuba's EGREM Studios, home of the Buena Vista Social Club, and featured a band of young Cuban musicians, including Harold Lopez Nussa.

[citation needed] The Brighton Port Authority debuted in 2008 with a collaboration with David Byrne and Dizzee Rascal titled "Toe Jam", along with a video featuring nude dancers with censor bars on them, making pictures and words with them.

[citation needed] The soundtrack album for the TV series Heroes also includes the Brighton Port Authority's track "He's Frank (Slight Return)" (a cover of a song by The Monochrome Set), with Iggy Pop as vocalist.

An alternative club version was released under the title "He's Frank (Washing Up)", with the video featuring some footage of Iggy Pop acting and saying lyrics.

[26] On 20 June 2013, Cook released his first charting Fatboy Slim single in seven years; "Eat, Sleep, Rave, Repeat" with Riva Starr and Beardyman.

It comes with a music video, his first in nearly 20 years, and features many celebrities using deepfake technology such as David Bowie, Bill Murray and Muhammad Ali.

[citation needed] Cook produced the single "Mama Do the Hump" by fellow Brighton band Rizzle Kicks released in December 2011 which peaked at number 2 in the charts.

[40] In 2006, Fatboy Slim filled the Saturday headline slot at the Global Gathering festival at Long Marston Airfield in the English Midlands.

Also in 2009, he played in Marlay Park, Dublin, alongside David Guetta, Dizzee Rascal and Calvin Harris, as well as one huge performance at the Sziget Festival in Budapest.

[50] On 25 September 2011, Fatboy Slim headlined the Terrace at Ibiza's famed Space Nightclub's We Love Sundays closing party.

On 29 October 2011, Fatboy Slim opened at the San Francisco Bill Graham Civic Auditorium, following up on the 30th, closing out the Red Bulletin/Le PLUR Stage at the Voodoo Music Experience in New Orleans, Louisiana.

On Saturday, 24 March 2012, Fatboy Slim performed a live DJ set on the main stage at Ultra Music Festival in Miami, Florida.

In December 2014, Fatboy Slim played three sold-out shows including The Warehouse Project in Manchester & O2 Brixton Academy, with supporting acts such as VAS LEON with Arthur Baker for Slam Dunk'd and DJ Fresh.

[55][56] On 15 May 2016, he played a private two-hour set "Baby Loves Disco" for preschool children and their parents during the festival Brighton Fringe holding.

[58] In October 2019, Cook performed a mashup of his track "Right Here, Right Now" and Greta Thunberg's United Nations speech during a concert in Gateshead, England.

These primitive 1980s block parties are recalled in the music documentary South Coast, which documents Brighton's cult hip hop scene from its grass roots to the present day.

Due to an extended stay in the rehabilitation centre, his performance at Snowbombing, a week-long winter sports and music festival held in the Austrian ski resort of Mayrhofen, was cancelled, with the slot being filled by 2ManyDJs.

[70] Bands Studio albums Cook appears in the documentary Tripping (1999) directed by Vikram Jayanti and written by Jeff Taupler about Ken Kesey and the Merry Pranksters.