[1] It is the involvement of liver tissue by trophozoites of the organism Entamoeba histolytica and of its abscess due to necrosis.

[2] The two most common manifestations of E histolytica include colitis (bloody stool with mucus, abdominal pain, and/or diarrhea), and discovery of a liver abscess on imaging.

[2] Although medical management using long courses of antibiotics have proven to be successful, Drainage of the abscess is the mainstay treatment.

Histopathological findings revealed that the chronic phase of amebic liver abscess in humans corresponds to lytic or liquefactive necrosis, whereas in rodent models there is granulomatous inflammation.

However, the use of animal models has provided important information on molecules and mechanisms of the host/parasite interaction in amebic liver abscess.