He was one of the first to join a group, led by Theodore Weld, that left Oneida, eventually enrolling as students at the new Lane Seminary near Cincinnati, Ohio.

[2] During the summer of 1835, in order to raise money to further his education, Dresser traveled around the South selling the Cottage Bible.

[7]: 261  From his "papers, pamphlets, correspondence and statements", the self-appointed Committee found him guilty of: A newspaper reporting the case commented editorially that Dresser's crime "might possibly lead to the violation by blacks of our wives and daughters".

[11] Dresser published in the Cincinnati Daily Gazette the story of what had happened to him, twice had it reprinted in pamphlets, plus the American Anti-Slavery Society issued it the following year, accompanied by other testimony on slavery.

[13][14] Descriptions in Southern newspapers support his account, although they call the Bible-selling a sham obscuring what according to them was his alleged real purpose: distributing abolitionist literature and fomenting a slave insurrection.

He then went to Berkshire County, Massachusetts, and in 1839 to Jamaica to assist another Lane Rebel, David Ingraham, in missionary work among the "Negroes".

[16][2] His wife died in 1850, and in 1851 he married another former Oberlin student, Ann Jane Gray; Adeline Minerva Dresser was their daughter.

[17] From 1852 to 1865 Dresser was pastor of churches in Trumbull and Ashtabula Counties, Ohio,[18] in the Western Reserve, Underground Railroad center and the most anti-slavery region of the country.

At some point towards the end of his life Dresser and his wife went to live in Lawrence, Kansas, with one of their children, and both Amos and Ann Jane died there.