Ampelocissus ascendiflora is a herbaceous climber with a longitudinally ridged stem, up to 3 mm across, often white tomentose when young, turning brown when older.

The tendrils are simple and each has a prominent, ovate bract, similar to the stipules.

The leaf is white-tomentose when young, turning brown below and sparsely hairy above when older.

The flower has red petals and a yellow disc.

The medicine can slowly lower the blood sugar levels.