In the Thesaphiban administrative reforms of King Chulalongkorn (Rama V) the city became the center of monthon Phitsanulok.

The distinction between the basins is blurry in this region, as the terrain is flat, and residents have diverted much of the water flow for agriculture over the years.

[6] There are 11 Christian churches in Mueang Phitsanulok District and muslims have their Masjid Abubak Pakistan mosque.

Ban Mai has not covered parts of tambons Wang Nam Khu and Wat Phrik since 1999.

Livestock farming produced commodities from chicken 597,497; duck 101,252; swine 16,732; cattle 3,540; buffalo 1,736; goat 2,446 and goose 141.

Yanyon tour operates its own private bus station (Sua Thim) with only a busline to Bangkok.

There are eight radio stations in the district:[28] In 2006, there were reported cases of leptospirosis among residents of Mueang Phitsanulok, contracted from standing water.