It is attached to Amrita University school of medicine and is one of the largest medical facilities in India with a total built-up area of over 3.33 million sq.ft, spread over 125 acres of land.

[2] Amrita hospital at Kochi offers facilities comprising 31 modern operating theatres, 275 equipped intensive care beds, a fully computerised and networked Hospital Information System (HIS), a fully digital radiology department, a 24/7 telemedicine service and a clinical laboratory.

The foundation stone for a second Amrita Hospital in Faridabad, Haryana was laid on May 9, 2016, to serve the Delhi National Capital Region.

The 'Innovation in Medical Technology' award was accepted by Dr. Mahesh Kappanayil for developing a 3D printing model in congenital heart surgery.

[7] In December 2011, nurses at the Amrita Institute of Medical Sciences and Research Centre went on strike against the hospital management, demanding a wage hike.

[8] The strike was called when leaders of the United Nurses' Association claimed that they were beaten by members of the hospital staff.

The hospital allegedly forced a trans woman to undergo conversion therapy, an unscientific and harmful practice banned in India by the National Medical Commission.