[4][5][6] In 2018, Karle was an Artist Diplomat[7][8] sponsored by the U.S. Department of State, for a cultural exchange initiative in conjunction with the Copernicus Science Center in Poland where she led workshops focusing on women's empowerment in STEAM fields.

The narrative of illness, with all its fears, hopes, and the quest for healing, constitutes a common thread in my research and work.

[17] In the same year, Resonation involved an EEG neuroheadset connected to a Chladni plate to generate bio-signals into visuals and sounds.

[11] Regenerative Reliquary (2016) is a sculpture that features a 3D-printed bioprinted hydrogel scaffold shaped like the bones of a human hand placed inside a glass vessel.

[31][32] The artworks are novel evolutionary forms based upon extinct species to explore “hypothetical evolutions through technological regeneration”, 3D printed in biocompatible material.

[33] Her AI and bio-AI hybrid artworks have been in museum exhibitions including: Artificial Intelligence: AI / The Other I Ars Electronica Linz, Austria,[4] La Fabrique Du Vivant Centre Pompidou, Paris, France,[26] and Future and the Arts: How Humanity Will Live Tomorrow Mori Art Museum, Tokyo, Japan.