The Amyot River flows through the municipalities of Saint-Bernard-de-Michaudville, Saint-Denis-sur-Richelieu and Saint-Charles-sur-Richelieu, in the MRC La Vallée-du-Richelieu, in the administrative region of Montérégie, on the south shore of Fleuve Saint-Laurent, in the southwest of province from Quebec, to Canada.

The main hydrographic slopes neighboring the "Amyot river" are: The Amyot River takes its head water from agricultural streams draining the area east of the municipality of Saint-Denis-sur-Richelieu, south of Saint-Bernard-de-Michaudville and west of Saint-Jude, in 5th rang.

The Amyot River first flows 2.7 km northwest in the forest, collecting the water from the Albert-Tourigny stream.

The river then flows 4.2 km southwest in agricultural areas passing east of the village of Saint-Denis-sur-Richelieu to route 137; and 4.8 km south-west in agricultural zones almost parallel (on the east side) to the Richelieu River, up to its mouth.

The toponym "Rivière Amyot" was formalized on December 5, 1968 at the Place Names Bank of the Commission de toponymie du Québec.