A 2014 classification placed a large proportion of the genera in the family Rutaceae in Amyridoideae.

[1] In 2012, based on molecular phylogenetic methods, Groppo et al. divided Rutaceae into two subfamilies, a small Cneoroideae and a very large subfamily Rutoideae s.l.

[3] A 2014 classification by Morton and Telmer added the subfamily Aurantioideae, and split the remaining Rutoideae s.l.

[2] Until 2021, molecular phylogenetic approaches had only sampled between 20% and 40% of the genera of Rutaceae.

The two main clades recognized by Groppo et al. in 2012 were upheld, but Morton and Telmer's Amyridoideae was polyphyletic and did not include the type genus.