She was born in a Sárapuszta (modern-day Šarapusta) near the Bačkan town of Bajmok, between Sombor and Subotica, at that time in Bács-Bodrog County, Kingdom of Hungary, Austria-Hungary to a family of Bunjevac origins.
Ana Bešlić was one of the most important representatives of modern sculpture in Yugoslavia and Serbia.
She attended schools in Zagreb, Graz and Vienna, but she developed her artistic education at the Academy of Fine Arts in Belgrade in 1949.
Part of her works were donated to the city of Subotica, including the monument of Blaško Rajić.
Rajko Ljubič, a film director from Subotica, made a documentary about her in 2005.