Blanco started her career in radio in 1980 as a contributor of Cadena SER, later in 1989 she debuted in television as host, along with Agustín Bravo, of the cultural-oriented program Zip-zap in Telemadrid.

Since 28 September 1992, she anchored the different editions of Telediario –afternoon, evening, and weekend– in different seasons, making her the longest running presenters in the history of the newscast, celebrating her thirty years in 2020.

[5] On 11 September 2001, she opened Telediario 1 with the breaking live feed of the World Trade Center's North Tower in New York since it had been hit a few minutes before.

She hosted that newscast, narrating the events live, for more than seven hours straight, making it the longest Telediario news bulletin in its history.

[7] Although just a few days later she covered from London the events after the death of Queen Elizabeth II, this being her last work onscreen for the newscast.