Her musical career began in 2016, when she released her debut single "No Soy Como Tú Crees".

Since then, she managed to deliver several hit songs both in Italy and Spain, becoming one of the most listened Spanish artists of the streaming era.

[4] Hugely popular in Spain and Portugal,[citation needed] Ana Mena has also gained a significant fanbase in France, Italy, Romania, Greece, Malta and Egypt.

According to her record label, Sony Music, as of 2024, she was credited for sales equivalent to 1 Diamond cetification in France, besides 60 Platinum and 10 Gold certifications in between Italy and Spain.

Two of Ana Mena's recent singles, "Música Ligera" and "Un Clásico", are covers of Italian pop songs: "Musica leggerissima" by Colapesce and Dimartino and "Superclassico" by Ernia, respectively.