Together with Amadeus, five co-hosts alternated during the five evenings: Ornella Muti, Lorena Cesarini, Drusilla Foer, Maria Chiara Giannetta and Sabrina Ferilli.

[2] Besides these, Orietta Berti and Fabio Rovazzi hosted parts of the show (for sponsorship reasons) from the cruise ship Costa Toscana off the shore of Sanremo.

On 20 October 2021, the RAI commission for Sanremo Music Festival 2022 announced a list of 711 acts, but only 30 artists coming from all Italian regions – excluding Basilicata and Valle d'Aosta – and from abroad were selected in the first phase.

After the auditions, a RAI commission – composed by Amadeus, Gianmarco Mazzi, Claudio Fasulo, Massimo Martelli and Leonardo de Amicis – identified 4 finalists for the competition among the 330 acts:[9][10]

[26] This was highly criticized by the Italian public, resulting into a second declaration by Coletta, claiming that there was a "misunderstanding" and that the singers would also be required to show their proof of vaccination upon entrance at the festival.