[1] The club currently competes in the regional Lasithi FCA A Division Championship, the top-level amateur football division in Lasithi, and host their home games at the «Manos frantzikinakis» Stadium in Ierapetra.

Their greatest accomplishments to date include their promotion to the Gamma Ethniki, the third tier of the Greek football league system in 2014, and reaching the Semi-Finals of the Greek Football Amateur Cup in 1993.

During the 1992−93 season, Anagennisi reached the Greek Football Amateur Cup Semi-Finals for the first time in their history, but were eliminated by eventual competition winners Kozani during penalty shootout.

[1] In 2014, they achieved promotion to the Gamma Ethniki for the first time in club history, but were instantly relegated at the end of the season.

At the start of 2010−11 season, Anagennisi merged with the other two clubs representing the town of Ierapetra, O.F.