It is the oldest and most successful football club representing the town of Ierapetra, hometown of one of the greatest Cretan players of all time: Petros Vouzounerakis,[1] of whom the club's home ground is named after (Ierapetra Municipal Stadium «Manos Frantzikinakis»).

Ierapetra was founded in 1970 as a result of a merger between Thyella and Diagoras, the two clubs based in the town at the time.

Ierapetra played in the Pan-Hellenic Amateur Championship, which used to be the unofficial third tier of the Greek football league system.

During the following decades, the club had a significant presence in the Delta Ethniki (4th level in the national league pyramid) of which they earned promotion to the Gamma Ethniki in 2006 after winning the Cretan Group championship title.

In 2017, the club once again achieved promotion to the Gamma Ethniki after winning the Lasithi regional championship,[3] where it still competes.