Analytical Chemistry is a biweekly peer-reviewed scientific journal published since 1929 by the American Chemical Society.

Articles address general principles of chemical measurement science and novel analytical methodologies.

Topics commonly include chemical reactions and selectivity, chemometrics and data processing, electrochemistry, elemental and molecular characterization, imaging, instrumentation, mass spectrometry, microscale and nanoscale systems, -omics, sensing, separations, spectroscopy, and surface analysis.

It is abstracted and indexed in Chemical Abstracts Service, CAB International, EBSCOhost, ProQuest, PubMed, Scopus, and the Science Citation Index Expanded.

According to the Journal Citation Reports, it has a 2022 impact factor of 7.4.