AFNI is actively developed by the NIMH Scientific and Statistical Computing Core and its capabilities are continually expanding.

AFNI runs under many Unix-like operating systems that provide X11 and Motif libraries, including IRIX, Solaris, Linux, FreeBSD and OS X. Precompiled binaries are available for some platforms.

AFNI is available for research use under the GNU General Public License, the included SVM-light component is non-commercial and non-distributable.

[5] One of AFNI's initial offerings improved the approach to transforming scans of individual brains onto a shared standardized space.

In this way researchers can view activation patterns while more easily taking into account physical cortical features like gyri.