In 2001, Anandsami was a part of the Indian Tamil remake of the Hindi television series Kyunki Saas Bhi Kabhi Bahu Thi.
[1] Finding chances hard to come by, he joined the Chennai-based theatre troupe Koothu-P-Pattarai in 2002, where he performed for eight years, before moving on to work with another group, Perch.
[1] Despite making small appearances in films and television during the 2000s, Anandsami was able to establish himself as a prominent theatre actor in the Chennai acting circuit.
Rajanarayanan's collection of short stories titled Nattuppura Kadhai Kalanjiyam with Anandsami reprising his role from the original play.
[8] A critic stated that "Actors Anand Sami, Maya S. Krishnan and Ravindra Vijay were in their elements with their seamless blend of art and entertainment".