Throughout the mid-1990s producers claimed to be intrigued by her voice's unusual tone, but Anastacia would be continuously told that "her sound just didn't quite fit into any category".

Anastacia attracted the interest of record labels after appearing on The Cut hosted by rapper Lisa "Left Eye" Lopes .

The song became an overall hit, in 2001, peaking in Denmark, Italy, Norway, and Switzerland, and reaching the top ten in several other mainland European countries.

People reviewed her album, writing "Anastacia is most successful when she shifts gears on more reflective, folk-tinged pop-rock tunes such as "Overdue Goodbye" and "How Come the World Won't Stop" on which her more nuanced vocals flow naturally.

"[33] Anastacia joined Celine Dion, Shakira, Cher, Mary J. Blige, Dixie Chicks, and Stevie Nicks for VH1 Divas Las Vegas in 2002[34] and she also contributed the song "Love Is a Crime" to the Chicago soundtrack.

Anastacia sang "Boom" the official song for the 2002 FIFA World Cup held in South Korea and Japan at the opening ceremony.

According to an interview she gave in 2005 on British music station The Box, her voice lost its power and she became unable to record, so she spent a long time writing and trying to create a sound with which she could finally be happy.

As stated on the Australian talk show Rove in 2004, Anastacia wanted to have more edge to her vocals as she felt something was missing from her previous work.

Anastacia released three further internationally successful singles; "Sick and Tired" (which gave her another number one in Spain and another UK top five single), "Welcome to My Truth" (her best-selling hit in Spain), and the ballad "Heavy on My Heart", sales of which went towards the Anastacia Fund (her charitable organization providing research funding for breast cancer).A small batch of her self-titled album were released with a bonus DVD, poster and slip case.

[citation needed] On July 24, Anastacia announced that her fourth studio album Heavy Rotation would be released in Europe and Asia on October 27, 2008 (and elsewhere in 2009).

The album featured collaborations with producers Ne-Yo, The Heavyweights, Lester Mendez, J.R. Rotem, and Rodney Jerkins, departing from the pop rock sound of her previous material.

[45] In November and December 2009 Anastacia, Chaka Khan and Lulu were headlining the Here Come the Girls a special Christmas concert that visited the United Kingdom only.

"[48]During the summer of 2010 Anastacia became one of the main judges on British talent series Don't Stop Believing, a contest inspired by the musical comedy-drama Glee.

Following "Stalemate", Anastacia released "Safety", a duet with Russian singer Dima Bilan, recorded in Los Angeles in May 2010.

The song was performed live for the first time at the Muz-TV Music Awards Moscow in June 2010 and was released as a single in Russia in August 2010.

On August 17, Natalia and Anastacia recorded a collaborative single, "Burning Star", which was released on September 17, 2010, to promote the concert series.

[52][53] In February 2011, Anastacia was a guest at the Gigi D'Alessio concert at Radio City Music Hall in New York, performing as an opening act.

[55][56] However it was later revealed that she had to reject the judging offer due to contractual agreements for the Night of the Proms European winter tour as well of the release of her independent cover album.

[63] Throughout November and December 2012 Anastacia took part in the annual Night of the Proms, a series of concerts held in Belgium, the Netherlands, and Germany which combine classical music with famous pop songs.

[citation needed] On February 27, 2013, Anastacia announced that she had cancelled her European tour because she was diagnosed with breast cancer for the second time and was undergoing treatment.

Anastacia later confirmed via her Twitter account that she was writing and recording songs for her sixth studio album, including working with producers John Fields and Steve Diamond.

It was quickly met with a positive reaction from music critics, with MTV's Brad Stern naming it one of the "5 Must-Hear Pop Songs of the Week!"

[71] After returning to her promotional tour Anastacia played numerous festivals throughout Europe including headlining Manchester Pride[72] which was heavily praised.

During the same month Anastacia attended The Children For Peace Gala at Spazio Novecento in Rome where she received the special artist award.

As I mentioned earlier, she communicated with the crowd in a hilarious yet lovely manner – thanking everyone for their support throughout, making jokes and also sending positive messages surrounding mental health and kindness.".

[107] On May 19, 2023, Anastacia was a guest performer as Kangaroo on the French series Mask Singer, where she sang "Don't Let the Sun Go Down on Me" by Elton John.

Anastacia performed a cover of AC/DC's "You Shook Me All Night Long" with Celine Dion at the VH1 Divas Las Vegas, a concert to benefit The VH1 Save The Music Foundation.

[124] The single "Sing" was released on World AIDS Day, December 1, 2007, in conjunction with Annie Lennox's appearance at the Nelson Mandela 46664 concert in South Africa.

She has appeared in television commercials for Mastercard's "Something for the Fans" campaign,[146] Škoda,[147][148] Honda, and Dr Pepper, in which she sang "Be You" with Cyndi Lauper.

[149][150] She has graced the covers of numerous international magazines, including Ecuador's Cosmopolitan; Germany's Maxim; Bulgaria's Eva; Italy's Grazia; UK's Fault,[151] Fabulous and Love Sunday and the Netherlands' Veronica.