It was founded by the Poor Handmaids of Jesus Christ in 1937 as an extension of DePaul University for the training of Catholic novices and candidates of the Poor Handmaids of Jesus Christ.

Ancilla College focuses on serving the seven surrounding counties of Indiana.

In 2021 Ancilla College was merged into Marian University, a fellow Catholic institution based in Indianapolis,[1] as a regional campus.

The Ancilla Chargers competed in the Michigan Community College Athletic Association of the National Junior College Athletic Association.

Their soccer, volleyball, baseball and softball games were broadcast by the Regional Radio Sports Network.