Saint Joseph High School (commonly referred to as St. Joe) is a Roman Catholic college preparatory high school located in South Bend, Indiana.

Formerly located adjacent to the campuses of the University of Notre Dame, St. Mary's College, and Holy Cross College, in 2012, the school moved to a new location about a mile south of Notre Dame.

Contributions from South Bend and Mishawaka parishioners enabled building the school on 5.7 acres (23,000 m2) of land donated to the Diocese of Fort Wayne-South Bend by the Brothers of Holy Cross.

From 1953 to 1968, Saint Joseph's High School had separate divisions for boys and girls.

St Joe has been named a Blue Ribbon school by the United States Department of Education.