[3] Bishop Luers' education departments consist of art, business, religion, English, foreign language, mathematics, and social studies.

Luers also has a spirited neighborhood rivalry with South Side High School, which is often termed "The Battle for Calhoun Street."

Bishop Luers has been to the Indiana state finals for football sixteen times, including four consecutive years, 1999 through 2002.

[9][10] The Knights' roster has included many accomplished players who have gone on to play successfully at the professional and NCAA Division I levels.

Among the most notable are Jack Johnston star quarterback, who led the Knights to their best regular season record to date.

Coinciding with the 2004 hiring of head coach James Blackmon, Sr., recent seasons have seen championship success for the boys' basketball team.