Andre Smith (born April 20, 1997) is an American professional football linebacker.

[1] He committed to play football for the North Carolina Tar Heels in October 2013.

He made 113 tackles, second on the team, along with one interception, one sack, three pass deflections, and one forced fumble.

[4] As a junior in 2017, Smith suffered a knee injury in North Carolina's second game against Louisville, forcing him to miss the remainder of the season.

[10] On August 31, 2020, Smith was traded to the Buffalo Bills for a conditional 2023 seventh-round pick.

[18] Smith was suspended the first six games of the 2022 season for violating the league’s policy against performance-enhancing substances.