He played college football for the Maryland Terrapins, and was selected by the Carolina Panthers in the first round of the 2018 NFL draft.

[3] Moore played college football for the Maryland Terrapins from 2015 to 2017 under head coaches Randy Edsall, Mike Locksley, and D. J.

[18] In a Week 11 loss to the Detroit Lions, Moore had a breakout game with seven receptions for 157 yards and a touchdown.

[20] He was named to the PFWA All-Rookie Team, becoming the second Panthers receiver to claim this award, joining Rae Carruth in 1997.

[25] In Week 2, Moore recorded eight receptions for 120 receiving yards in a 17–31 loss to the Tampa Bay Buccaneers.

[40] Moore's touchdown was a 62-yard catch that appeared to set up the Panthers to win the game with only 12 seconds remaining.

However, Moore took off his helmet out of bounds and was flagged for unsportsmanlike conduct, which moved the extra point back.

[46] On September 24, during Week 3 against the Kansas City Chiefs, Moore recorded three receptions for 41 yards and a touchdown, his first of the year, during the 41–10 loss.

[47] On October 5, in Week 5 against the Washington Commanders, Moore recorded eight catches for 230 yards and three touchdowns in a Bears victory, with a final score of 40–20.

[49] In Week 12, Moore surpassed 1,000 receiving yards in a season for the fourth time in a road victory over the Minnesota Vikings.

In addition, the deal made Moore the first receiver in NFL history to have the first 10 years of his career guaranteed.

[51] In Week 5 of the 2024 season, against his former team, the Carolina Panthers, Moore had five receptions for 105 yards and two touchdowns in the 36–10 win.