[1] He played on Michigan's 1997 national championship team and had a 43-yard interception run-back for the winning touchdown in a 20–14 victory over Ohio State.
[2] Weathers also had a key sack of Ryan Leaf in Michigan's victory over Washington State in the 1998 Rose Bowl.
With the media attention focused on his teammate Charles Woodson, Weathers was sometimes referred to by the press in 1997 as Michigan's "other cornerback.
[8] Weathers made the final cut and played in the Giants' season opener against the Tampa Bay Buccaneers.
[8] In that game, his first in the NFL, Weathers intercepted a pass off Trent Dilfer and returned it for the winning touchdown as the Giants defeated Buccaneers, 17–13.
"[9][10] The Daily News reported, "Only a week ago, rookie Andre Weathers was sweating out the final cuts, and if not for the injuries to Jason Sehorn and Conrad Hamilton that created a need for cornerbacks, who knows?
But there he was yesterday, making perhaps the biggest play of the 17-13 win over the Bucs as he returned an interception eight yards for the go-ahead touchdown in the third quarter.
At the time, the New York Post noted: "This is especially cruel news for Weathers, who last Sunday made his debut this season.
The Giants were cautious in bringing Weathers back, but he reinjured the same knee in the 24–7 victory over the Philadelphia Eagles, will again need surgery and faces another year-long rehab.