Along with Marella, widow of his uncle Gianni Agnelli, and Allegra, he is descendants of an old Neapolitan noble family that held the titles of Prince of Castagneto and Duke of Melito, among others.

[24] During and after university, Agnelli started his career in the business world, including abroad in England and France at companies Iveco, Auchan Hypermarché, and back in Italy at Milan with Piaggio.

In November 2000, Agnelli moved to Paris to take on marketing responsibility for Uni Invest SA, a Sanpaolo IMI company specializing in the offer of asset management products.

[39][40] In January 2023, Agnelli announced his resignation from the position in Stellantis,[41] effective at the close of the 2023 annual general meeting of shareholders,[42][43] and that he would not reapply for the role in Exor.

[58][59] One of his first acts as new chairman was to appoint Sampdoria duo Giuseppe Marotta as director of sport and Luigi Delneri as new coach.

It took ten years to recover and return to the top Italians, not yet Europeans: now the club makes over €300 million, but in the meantime Real, Bayern, and the others have taken off.

[79][80][81] In doing so, after forty-eight years of absence, he became the fourth member of the Agnelli dynasty, after his grandfather, his uncle, and his father, to hold the club's premier executive charge.

[82][83][84] Under his mandate from the 2010s, Juventus established a victorious cycle, during which they won the Italian football championship for nine consecutive Serie A seasons; they broke an eighty-two years national record of five consecutive league wins, which was first achieved by Juventus under Agnelli's grandfather, and established a new national record with nine consecutivi scudetti.

[100][101][102] On the sporting side, the Agnelli presidency included the expansion and modernization of the club's property portfolio from the Juventus Stadium,[103][104] the J-Museum,[105][106] the J-Hotel,[107][108] the J-Medical,[109] and the J-Village complexs,[110][111] to the renewal of the club's corporate identity by adopting a pictogram of a stilized black and white J, a letter that is not used in the Italian alphabet, as logo.

[122] In regards to sports policy, Agnelli took a tougher position than that of the previous Juventus management,[77] led by Giovanni Cobolli Gigli and subsequently by Jean-Claude Blanc,[123] in the aftermath of the post-Calciopoli.

[75][76][148] This led to a dispute between Juventus, the FIGC, and Inter Milan,[149] the club that controversially received the 2006 scudetto but was later charged of sporting illicit when it was time-barred by the statute of limitations in 2011; citing disparità di trattamento (disparity of treatment),[150] Juventus asked the two scudetti back and sued the FIGC for €443 million for damages caused by their 2006 relegation.

Then-FIGC president Carlo Tavecchio offered to discuss reinstatement of the lost scudetti in exchange for Juventus dropping the lawsuit.

[155] On 24 July 2014, he became the director of the Lega Nazionale Professionisti Serie A,[25] and was nominated to be board member of the Foundation for General Mutuality in Professional Team Sports.

"[170] On 28 November 2022, Agnelli resigned as chairman of Juventus,[171] amid a sporting trial regarding the Plusvalenze scandal,[172][173][174] which in the case of Juventus represented 3.6% of the club's revenues during the investigated period,[175] related to the 2019–21 years,[176][177] after the capital gains case was reopened;[178][179][180] it was later revealed that during these years there were disagreements within the club,[181][182][183] including self-criticism of past transfers.

[197][198][199] On 27 August 2005, Agnelli married Emma Winter in a Roman Catholic ceremony in Villar Perosa, Piedmont, at the church of San Pietro in Vincoli.

[201][202] After the end of his marriage with Winter, which was finalized in April 2016,[203][204][205] Agnelli has been engaged to the Turkish former model Deniz Akalin since 2015;[206][207] they knew each other for several years, being the ex-wife of Francesco Calvo, the former marketing manager of Juventus.

[208][209] On 22 April 2017, the couple had a daughter, who was named Livia Selin;[210][211] her godfather was the incumbent president of UEFA, Aleksander Čeferin,[212][213] with whom Agnelli later came in contrast regarding the European Super League project.

[224] In 2016, prosecutor Ciro Santoriello acquitted Juventus and Agnelli of false accounting charges related to the 2015–16 years; not finding any irregularity, he dismissed the case.

[225] On 18 March 2017, following the opening of a lawsuit by Giuseppe Pecoraro from the Turin Public Prosecutor's Office, Agnelli was referred by the FIGC's Attorney General along with three other club executives.

[226] On 15 September, the FIGC reformulated its allegations, excluding a presumed Mafia association from the members of the incriminated club after Pecoraro's intervention to the Antimafia Commission in April;[227] the prosecutor asked for sanctions for the meetings of Agnelli with ultra groups and the sale of the tickets by the rest of the offenders beyond the limit allowed per person, which favoured ticket scalping.

On 20 January 2023, Agnelli was suspended for two years from holding office in Italian football as punishment for capital gain violations, amid the Plusvalenza scandal, which is related to the capital gains and false accounting,[231] and the reopened Prisma case,[232][233] which started in November 2021;[234][235] a preliminary hearing for the Prisma case is scheduled for March 2023.