Like Petrucci, whose similar Odhecaton had appeared eight years earlier in Venice, he began by publishing popular secular music.
What he did between 1522 and 1533 has not yet been determined, but he resumed his printing activities in 1533, still in Venice, this time working as an employee of Ottaviano Scotto, his previous collaborator from Rome.
It has been suggested that Antico spent the years from 1522 to 1533 in Lyon, possibly working with the famous printer there, Jacques Moderne, who was also from Istria.
While this technology was older than moveable type and more laborious to prepare, it allowed for high-quality prints when done by a fine craftsman, and Antico was acknowledged to be one of the finest woodblock printers of the time.
The graphic artist responsible for the cover page designs as well as the abundant illustrations in the Liber quindecim missarum and elsewhere was probably Giovanbattista Columba.