On October 29, 2024, in closing remarks on her show, Mitchell announced she will be leaving the full time anchor chair in early 2025.

Her father was the chief executive officer and partial owner of a furniture manufacturing company in Manhattan.

[7] In 2005, Mitchell's book, Talking Back... to Presidents, Dictators, and Assorted Scoundrels, (ISBN 978-0-143-03873-3), was published.

[9] A report in The Washington Post ("Bush Administration Is Focus of Inquiry CIA Agent's Identity Was Leaked to Media" by Mike Allen and Dana Priest, The Washington Post, September 28, 2003) that Mitchell had leaked Valerie Plame's identity led to her being questioned by the Federal Bureau of Investigation.

"[10] During a July 2005 news conference in Khartoum, Mitchell was forcibly ejected from a room after asking Sudanese President Omar al-Bashir some pointed questions.

Sean McCormack, the State Department's assistant secretary for public affairs, said to his Sudanese counterpart, "I'll convey your desires about not permitting reporters to ask questions, but that's all I'll do.

"[12][13] During an appearance on MSNBC on June 5, 2008, Mitchell referred to the voters of the southwest Virginia region as rednecks.

"[16] Having been led to believe that a clip showed that presidential candidate Mitt Romney was impressed by a touchscreen at a Wawa convenience store, Mitchell and contributor Chris Cillizza laughed when it was shown on Andrea Mitchell Reports,[17] alluding to a widely held myth that George H. W. Bush was unfamiliar with a supermarket scanner in an incident during his 1992 campaign.

The full clip puts his comments in the context of his claim that Wawa's "touchtone keypads" (touchscreens) show efficiency in the private sector compared to his statement that it took multiple filings of a 33-page government form for an optometrist to change his address.

[19][20][21][22] Mitchell briefly addressed complaints from the Republican National Committee and Romney's campaign the following day.

Introducing the full clip, Mitchell stated, "The RNC and the campaign both reached out to us, saying that Romney had more to say on that visit about federal bureaucracy and innovation in the private sector.

On September 7, 2011, Mitchell revealed that she had been diagnosed with breast cancer during a doctor's visit a few weeks earlier.