He is the only person to have served as host and moderator of more than one of the major U.S. political Sunday morning talk shows, which he did during his time at NBC.

[7] From 2003 to 2021, he hosted Fox News Sunday, and took high profile interviews with Barack Obama, Donald Trump, and Vladimir Putin.

[8][9] He made history when he became the first Fox News journalist to moderate a United States Presidential debate in 2016 between Donald Trump and Hillary Clinton.

[23] Leonard gave him early exposure to political journalism, hiring him as an assistant to Walter Cronkite at the 1964 Republican National Convention.

"[26][27] Although accepted at Yale Law School, he decided to work for The Boston Globe, where his boss described him as an "aggressive and ambitious reporter".

He first covered City Hall during the time Kevin White was mayor of Boston and later became a roving national reporter.

Wallace began his network journalism career with NBC in 1975, where he stayed for 14 years as a reporter with WNBC-TV in New York City.

That same year, he also served as chief White House correspondent (1982–1989) alongside contemporaries CBS's Lesley Stahl and ABC's Sam Donaldson.

[35] Sam Donaldson, ABC's outgoing chief White House correspondent, said he was "delighted" and "very pleased" that Wallace, his journalistic rival, would be joining the network saying, "I've always liked his work, I think he's going to be a plus.

"[38] Throughout his 18 years at Fox, Wallace had participated in coverage of nearly every major political event and secured several high-profile interviews with dignitaries and U.S. leaders.

[40] On March 3, 2016, Wallace joined Bret Baier, and Megyn Kelly in moderating the 2016 Republican Party Presidential debate on Fox News.

Afterward, Jennifer Rubin in The Washington Post said that, despite her strong disapproval of other Fox News commentators, "No one could watch the final debate and deny that Chris Wallace is among the best in the business.

"[45] The New York Times wrote, "Mr. Wallace mixed humor with scolding and persistence with patience to guide his charges toward the most substantive encounter of an unusually vicious election.

"[54] When Ford's testimony was criticized by conservative pundits, Wallace discussed how his daughters had related their own previously undisclosed experiences.

[57][58] Pavlich argued that Republicans should be allowed to deny Democrats the right to call witnesses during the trial citing the 1998 Investigation and Impeachment of Bill Clinton.

[61][62] In the midst of the ongoing nationwide Black Lives Matter protests over the murder of George Floyd, Wallace pressed Trump on his claim that Joe Biden, the presumptive 2020 Democratic presidential nominee wanted to "defund and abolish" the police by replying "No, sir, he does not.

This includes Frank Sesno, a professor at George Washington University who teaches a class on "the art of the interview", who stated, "He's very good at this.

"[75][76][77] Wallace further condemned Trump's wanting to halt votes from being counted by saying that it was "extremely irresponsible" and that he didn't think the courts would allow it.

[80] Wallace had complained to Fox management about its opinion hosts, in particular Sean Hannity's and Tucker Carlson's increasing emphasis on untruths about the January 6 United States Capitol attack and the outcome of the 2020 presidential election.

[83] At their Upfront presentation the following month, it was revealed that Who's Talking had gone back into production, and would make its new home at CNN and HBO Max.

[84] In its first season Wallace interviewed former Supreme Court Justice Stephen Breyer, actor George Clooney, representative Alexandria Ocasio-Cortez, comedian Billy Crystal, athlete Alex Rodriguez, musician Meghan Trainor, chef José Andrés, and author James Patterson.

[85] Other notable interviews throughout the rest of its run were with James Cameron, Hugh Jackman, Harrison Ford, Matt Damon, Bernie Sanders, Charlamagne tha God, Bill Maher, Larry David, and Stephen A. Smith.

Regular panelists included Lulu Garcia-Navarro, Kara Swisher, Kristin Soltis Anderson, and Reihan Salam.

[89] Wallace denied to Puck that he discussed a future role on CNN, and said that he decided with his wife to leave the network six months before his announcement.

[91] In December 2019, Wallace stated at the Washington Media Museum: "Trump is engaged in the most direct sustained assault on freedom of the press in our history.

"[92] He also stated that in his 50-year career in journalism, his highlights include "spending a week with Mother Teresa in Calcutta", covering Ronald Reagan across the world for ABC News, and interviewing Vladimir Putin in Helsinki, where he asked, "Why do so many people who oppose you end up dead?

[104] Wallace first developed a relationship with his father in his teens, after his older brother Peter died in 1962 climbing a mountain in Greece.

Wallace said that he did so for pragmatic reasons, in response to the party's preeminence in the city's politics, commenting: "If you want a say in who's going to be the next mayor or councilman, you have to vote in the Democratic primary."

In June 2020, Wallace published his third book, Countdown 1945: The Extraordinary Story of the Atomic Bomb and the 116 Days That Changed the World, with Mitch Weiss.

[118] In October 2024, Wallace published his fourth book, Countdown 1960: The Behind-the-Scenes Story of the 312 Days that Changed America's Politics Forever, again co-written by Weiss.