Born in Barcelona, Catalonia, Orlandi started his senior career with Deportivo Alavés, only managing three competitive appearances for the first team during his two-year spell,[2][3][4] with the Basques in Segunda División.

On 20 May 2006, as Barça were already crowned champions, Orlandi took part in his first – and only – La Liga match with the Catalans' main squad, pitching in at left back in a 1–3 away loss against Athletic Bilbao.

[7] In late September 2007, after an unsuccessful trial with Aris Thessaloniki FC, free agent Orlandi signed for Swansea City, moving to the Liberty Stadium on a one-year deal as the club was managed by his compatriot Roberto Martínez.

[11] On 4 July 2011, after having helped Swansea to its first-ever promotion to the Premier League, contributing 20 games to this feat, Orlandi penned a new one-year contract extension with the club.

Orlandi scored the fastest Premier League goal in five years on 28 April 2012, with a diving header from a Scott Sinclair cross after just 25 seconds.

[27] On 6 August 2018, Orlandi joined Indian Super League franchise Chennaiyin FC after a two-year stint with Novara Calcio in the Serie B.