[7] Stramaccioni also led Inter Primavera to the final of the 2011–12 NextGen series, after defeating Sporting CP at the Estádio Dr. Magalhães Pessoa, Leiria and Marseille on 21 March at Griffin Park in London.

After 14 months in charge of Inter and a difficult 2012–13 Serie A campaign which saw them finish in 9th place and thus fail to qualify for Europe for the first time in 15 seasons, the club announced on 24 May 2013 that Stramaccioni had been sacked and replaced by Walter Mazzarri.

[16] On 8 November 2015, Stramaccioni was appointed as manager of Super League Greece club Panathinaikos, signing a one-and-a-half-year deal until the end of the 2016–17 season.

The start of Panathinaikos' 2016-17 campaign in all competitions proved far beyond the fans' expectations, as it was characterized by a poor run of results, including defeats to Olympiacos (0-3), Xanthi (1-2) and Ajax (1-2 at home and 0–2 away), and marked by the team's elimination from the UEFA Europa League group stage with only one point in the first five fixtures.

[17] As a result of increasing fan outrage, further aggravated after Panathinaikos' 2-1 Greek Cup defeat to OFI, chairman Giannis Alafouzos decided to terminate Stramaccioni's contract with the club on 1 December 2016,[18] replacing him later that day with Marinos Ouzounidis.

[21] In July 2017, the club was eliminated in the third qualifying round of the UEFA Europa League after losing both matches against Red Star Belgrade (0-2 away and 0–1 at home).

[22] Three months later, Sparta were eliminated in the fourth round of the Czech Cup after losing at home (2–2 (aet) 2–4 (pen)) against Baník Ostrava.

[26] Upon being appointed, Stramaccioni declared that Meysam Teymouri, Farshad Mohammadi Mehr, Armin Sohrabian, Rouhollah Bagheri and Reza Karimi were not part of his plans for the coming season.

[39] As an expert of international and Qatari football, Stramaccioni was hired by RAI as a color commentator for the 2022 FIFA World Cup;[40] his first commentary, for the Argentina vs Saudi Arabia game, gained extensive coverage throughout social media for its intensity.