Through most of its history, Andrean has been staffed in part by members of the Basilian Fathers and the Sisters of Saints Cyril and Methodius.

The school colors are red and gold in honor of the martyrdom and subsequent glory of St. Andrew.

The school motto is "Magister Meus Christus," or "Christ is My Teacher."

Bishop Leo Aloysius Pursley from the Diocese of Fort Wayne and Bishop Andrew Gregory Grutka from the newly formed Diocese of Gary were instrumental in its creation.

This name comes from the address of the school, 5959 Broadway, and the year of its founding- 1959.