Born in 1790 in Argostoli[1] he belonged to the historical Metaxas family, which originated in Constantinople and moved to Kefalonia in the 15th century.

[6] When the revolution was declared, he rushed to Peloponnese and established, along with his brother Anastasios and his cousin Konstantinos, a military contingent of 350 men from Kefalonia[7] equipped with two cannons, contribution of Evangelinos Panas.

Claiming that they were chasing pirates, they boarded a ship belonged to Anastasios and Fokas Theodoratou brothers, which was equipped with 18 cannons, 50 sailors and 50 gunmen.

There, they were joined by other military captains (Vilaetis, Sisinis and Plapoutas) and then marched to Lalas, which was the foothold of notorious Albanian fighters.

[10] On 25 May 1822, in a unanimous decision, the "Executive Body" passed an act by which Metaxas was naturalized as a Greek Peloponnese citizen for his service to his country.

Along with Georgios Mavromichalis and Germanos III of Old Patras, he was sent by the Government to Verona in search for financial resources but also to persuade the Great Powers to not act against Greece, in which he succeeded with the help of his friend Ioannis Kapodistrias.

Following the 3 September 1843 Revolution, he received a mandate by Otto to form a government to prepare elections for a constitutional assembly.

A few days later, under the threat that he would resign unless his proposal was accepted, he managed to convince the cabinet to broaden the government with the participation of Alexandros Mavrokordatos and Ioannis Kolettis, leaders of the English and French party respectively.

In 1850, he was promoted to the rank of Lieutenant General and was decorated by King Otto with the Grand Cross of the Order of the Redeemer.

Andreas Metaxas also served as president of the Society for the Promotion of Education and Learning and many charity foundations.