In 1985 he was appointed professor at the University of Stuttgart, where he became the founding director of the Institute for Parallel and Distributed High-Performance Computer Systems in 1988.
On January 1, 1998 he was appointed scientific and managing director of the EML European Media Laboratory GmbH, which Klaus Tschira had founded in 1997.
In 2007, Andreas Reuter accepted the endowed chair for “Dependable Systems”, supported by the Klaus Tschira Foundation, at the University of Kaiserslautern.
Together with the Turing Award laureate James "Jim" Gray he published the book "Transaction Processing: Concepts and Techniques" in 1992, which became a standard reference work for researchers and developers around the world and was translated among others into Chinese and Japanese.
In addition to his research Andreas Reuter conducted numerous consulting projects and held lectures on many topics in both the university and industrial sectors.
He is involved in numerous advisory boards both in academia and industry and is among other positions an External Scientific Member of the Max Planck Institute for Computer Science (MPII) in Saarbrücken and of the Board of Trustees of the Max Planck Institute for Astronomy (MPIA) in Heidelberg.