Andrew is the primary transfer point between the Red Line subway and the MBTA surface bus routes into South Boston.

The station opened in June 1918 as the southern terminus of the Cambridge–Dorchester line, and quickly replaced Broadway as the primary streetcar transfer point for South Boston.

Andrew was the terminus of the line until November 1927, when Columbia, Savin Hill, and Fields Corner stations opened on the Ashmont branch.

[2] After political requests and lobbying efforts by the local community, the station underwent extensive renovation from 1990 to 1993 with a new bus shed and underground connections, including a crossover mezzanine between the Red Line platforms.

The restored original wood frame toll taker's booth from the 1920s is installed as a permanent display in the inbound-outbound crossover lobby.