Carmellini began his cooking career at age 14 in his hometown of Seven Hills, Ohio.
After a stint at San Domenico in New York City, Carmellini honed worked at restaurants in Europe, including Valentino Marcatili's two-star Michelin restaurant San Domenico in Emilia–Romagna, Gualtiero Marchesi di San Pietro all'Orto in Milan and Arpège in Paris.
As chef at A Voce, he earned a three-star New York Times review and a Michelin star.
[2] [3] In 2009, Carmellini opened Locanda Verde, a Tribeca Italian taverna, in Robert de Niro’s Greenwich Hotel with partners Luke Ostrom and Josh Pickard.
With his wife, Gwen Hyman, Carmellini is the author of two books of recipes and stories: Urban Italian, and American Flavor.