Sendejo was also a member of the Dallas Cowboys, New York Jets, Philadelphia Eagles, Minnesota Vikings, Cleveland Browns, and Indianapolis Colts.

He also participated in track & field for the Rangers; at the 2004 District 27-5A Championships, he placed third in the 400-meter dash (52.80 seconds), sixth in the triple jump (12.04m or 39'4") and fifth in the pole vault (3.53m or 11'6").

At Rice, Sendejo saw his senior season come to an early conclusion after suffering a severe high ankle sprain at East Carolina that required surgery.

He posted four double figure games on the season, including a career-best 18-tackle day at Marshall, the most by an Owl since Jeff Vanover was credited with 18 against SMU in 2001.

[5] On November 24, 2010, the Dallas Cowboys signed Sendejo to a two-year, $725,000 contract to join their practice squad as an unrestricted free agent.

Cowboys' quarterback Tony Romo stated during a press conference that Rob Ryan had made minor adjustments to the defense to prevent any information to possibly be passed on to the Jets.

[7] On December 11, 2011, Sendejo made his Minnesota Vikings' debut and recorded one solo tackle during their 34–28 loss at the Detroit Lions in Week 14.

[17] Sendejo entered training camp and competed for a roster spot as a backup safety against Jamarca Sanford, Robert Blanton, and Eric Frampton.

[18] Head coach Leslie Frazier named Sendejo the third strong safety on the depth chart to begin the regular season, behind rookie Harrison Smith and Jamarca Sanford.

[21] In Week 7, he made a solo tackle on Patrick Peterson during a five-yard punt return in the third quarter of a 21–14 win against the Arizona Cardinals.

[24] Throughout training camp, Sendejo competed to be the starting strong safety against Mistral Raymond, Robert Blanton, Jamarca Sanford, Brandan Bishop, and Darius Eubanks.

[25] Head coach Leslie Frazier officially named Sendejo a backup strong safety, behind Jamarca Sanford and Mistral Raymond, to start the regular season.

He started nine consecutive games at free safety (Weeks 7–15) after Harrison Smith was placed on injured reserve/designation to return due to a turf toe injury.

On December 8, 2013, Sendejo recorded three combined tackles, two pass deflections, and made his first career interception in a 29–26 loss to the Baltimore Ravens.

[33] He intercepted a pass by quarterback Joe Flacco that was originally intended for tight end Ed Dickson in the fourth quarter.

[17] On December 30, 2013, the Minnesota Vikings fired head coach Leslie Frazier after they finished fourth in the NFC North with a 5–10–1 record.

[35] On August 4, 2014, the Minnesota Vikings activated Sendejo off of their physically unable to perform list after he fully recovered from back surgery he underwent in April.

Head coach Mike Zimmer named Sendejo the backup free safety, behind Harrison Smith, to start the 2014 regular season.

Defensive coordinator George Edwards chose to keep Sendejo as the starting strong safety for the remaining two games (Weeks 16–17), although Blanton had recovered from his leg injury.

[17] During training camp, Sendejo competed against Robert Blanton, Antone Exum, and Anthony Harris to retain the job as the starting strong safety.

[41] He started in the Minnesota Vikings' season-opener at the San Francisco 49ers and made three solo tackles and blocked a field goal in their 20–3 loss.

[42] On the 49ers' opening drive, Sendejo blocked a 28-yard field goal attempt by kicker Phil Dawson and it was recovered by teammate Marcus Sherels at the Vikings' 44-yard line.

On November 8, 2015, Sendejo collected seven combined tackles, a pass deflection, and was credited with half a sack to mark the first of his career during a 21–18 overtime victory against the St. Louis Rams in Week 9.

[45] On January 3, 2016, Sendejo collected a season-high 14 combined tackles (nine solo) in the Vikings' 20–13 win against the Green Bay Packers in Week 17.

[48] Sendejo finished the 2016 season with 69 combined tackles (45 solo), four pass deflections, two fumble recoveries, two interceptions, and was credited with half a sack in 14 games and 14 starts.

Head coach Mike Zimmer officially named Sendejo and Harrison Smith the starting safety duo to begin the 2017 regular season.

On January 10, 2018, Sendejo collected four solo tackles, deflected two passes, and made an interception during Minnesota's to 29–24 comeback victory against the New Orleans Saints in the NFC Divisional Round.

He intercepted a pass attempt thrown by quarterback Drew Brees in the first quarter that was originally intended for wide receiver Ted Ginn Jr.[55] The following week, Sendejo collected four solo tackles as the Minnesota Vikings were routed 38–7 by the Philadelphia Eagles in the NFC Championship Game.

[62] In Sendejo's first game back with the Vikings, he recorded a team high 7 tackles and intercepted a pass thrown by Brandon Allen in the 27–23 comeback win over the Denver Broncos in week 11.

[63] In week 14 against the Detroit Lions, Sendejo intercepted a pass thrown by rookie quarterback David Blough late in the fourth quarter to seal a 20–7 Vikings win.