[2] Whitworth played college football for the LSU Tigers, receiving second-team All-American honors in 2006, and was selected by the Bengals in the second round of the 2006 NFL draft.

He participated in the first-ever U.S. Army All-American Bowl game on December 30, 2000, along with other future LSU players Marcus Spears, Marquise Hill, and Ben Wilkerson.

The team went 13–1 en route to a BCS national title with a Sugar Bowl defeat of Oklahoma.

In 2004, Whitworth led the team with 799 snaps from scrimmage as the Tigers went 9–3 with a Citrus Bowl berth against Iowa.

He was credited with 96 key blocks, including 66 knockdowns, and played every offensive snap during a four-game stretch against Georgia, Florida, Troy, and Vanderbilt.

He earned All-Southeastern Conference first-team honors in each of his last two seasons, including a consensus nod as a senior.

On July 25, 2008, Whitworth agreed in principle to a four-year extension worth a reported $30 million that would keep him in Cincinnati through 2013.

In 2009, head coach Marvin Lewis decided to move Whitworth from guard to left tackle and saw immediate impact.

He started all sixteen games of the season, allowing just five sacks and helping running back Cedric Benson have a breakout year rushing for 1,251 yards.

On December 12, 2010, Whitworth caught a one-yard touchdown pass from Carson Palmer against the Pittsburgh Steelers.

[8] In January 2013, for the first time in his career, Whitworth was named a left tackle on the AFC Pro Bowl team.

Due to his success, many pundits and experts have claimed that Whitworth was snubbed out of a second Pro Bowl berth,[10] however, he was named second-team AP NFL All-Pro.

[16] In 2018, Whitworth helped the Rams reach Super Bowl LIII after they defeated the Dallas Cowboys in the Divisional Round and New Orleans Saints in the NFC Championship Game.

[18] In the eighth week of the 2019 season, the Rams defeated the Bengals 24–10, giving Whitworth a victory over his former team.

[20] On November 16, Whitworth was placed on injured reserve, as he was carted off the field after suffering a torn MCL and damaged PCL in a 23–16 home win over the Seattle Seahawks in Week 10.

… I now live life with a new clear mind, whole heart, and a burning passion to spread Christ's love.