[7] McLeod's quick rise up the depth chart continued in the preseason after he led the Rams with 12 combined tackles and earned reps ahead of Darian Stewart at strong safety during practice.

[8] Head coach Jeff Fisher named McLeod the backup free safety behind Quintin Mikell to begin the regular season.

[12] McLeod entered training camp competing for a job as a starting safety after Quintin Mikell was released and Craig Dahl departed in free agency.

Head coach Jeff Fisher named McLeod the starting strong safety after Darian Stewart missed the preseason and first three games due to a soft tissue injury.

[16] New St. Louis Rams' defensive coordinator Gregg Williams named McLeod the starting free safety, along with T. J. McDonald, after Darian Stewart departed for the Baltimore Ravens.

[17] The following week, McLeod made five solo tackles and intercepted a pass by quarterback Jameis Winston in the Rams' 19–17 win at the Tampa Bay Buccaneers.

[19] Head coach Jeff Fisher retained McDonald and McLeod as the starting safety duo to begin the 2015 regular season.

[21] In his last season with the St. Louis Rams, McLeod recorded 82 combined tackles (59 solo), five pass deflections, three forced fumbles, and an interception in 16 games and 16 starts.

[24] McLeod received contract offers from the Philadelphia Eagles, Cleveland Browns, Jacksonville Jaguars, and Tampa Bay Buccaneers.

[28] He started the Eagles' season-opener against the Browns and recorded four combined tackles and intercepted a pass by quarterback Robert Griffin III in their 29–10 victory.

The following week, he recorded seven solo tackles, broke up a pass, made an interception, and his first career sack on Sam Bradford during a 21–10 victory against the Vikings.

[30] He finished his first season with the Philadelphia Eagles with a career-high 83 combined tackles (72 solo), seven pass deflections, three interceptions, a forced fumble, and a sack in 16 games and 16 starts.

[11] Defensive coordinator Jim Schwartz retained McLeod and Jenkins as the starting safeties and also had Patrick Robinson, Sidney Jones, and Rasul Douglas added to their secondary.

In Week 2, McLeod recorded two combined tackles before leaving the Eagles' 27–20 loss at the Kansas City Chiefs in the second quarter after sustaining a hamstring injury.

[35] The Eagles finished the 2017 season atop the NFC East with a 13–3 record and clinched a playoff berth and home field advantage.

On January 13, 2018, McLeod started his first career playoff game and recorded seven solo tackles and a sack on Matt Ryan during the Eagles' 15–10 victory against the Falcons in the NFC Divisional round.

[36] On September 29, 2018, McLeod was placed on injured reserve after undergoing surgery to repair a torn MCL he suffered in Week 3 against the Indianapolis Colts.