He was selected with the first overall pick in the 2014 NBA draft by the Cleveland Cavaliers after one year of college basketball with the Kansas Jayhawks.

Wiggins grew up in Canada before attending his last two years of high school in the United States, where he was named a McDonald's All-American.

After a preseason trade to the Minnesota Timberwolves, Wiggins earned NBA Rookie of the Year honors for the 2014–15 season.

[2][4][5][6][7] He is the son of former NBA player Mitchell Wiggins, an American, and former Olympic track and field sprinter Marita Payne-Wiggins, a Canadian who is originally from Barbados.

In his 2010–11 sophomore year, he led the school's AAAA basketball team to a 44–1 record, en route to winning the Ontario provincial championship.

[15] On February 7, 2013, after an article in Sports Illustrated criticized Canadian basketball and Wiggins' work ethic,[18] he responded later that day, scoring 57 points in a 111–59 win over Marietta College.

[4] On January 13, 2014, Wiggins scored 17 points and collected 19 rebounds in a 77–70 victory over Iowa State, becoming only the second freshman in the last 15 years (along with Michael Kidd-Gilchrist) to amass those numbers in a win against a ranked opponent.

[30][31] On January 22, 2014, Wiggins was named a Top 25 Finalist for the John R. Wooden Men's Player of the Year award by the Los Angeles Athletic Club.

[50]On November 8, 2016, Wiggins scored a career-high 36 points and hit a career-best six three-pointers in a 119–110 loss to the Brooklyn Nets.

[53] The following day, he scored 40 points in a 112–99 win over the Denver Nuggets, becoming just the second Minnesota player to record back-to-back 40-point games.

[56][57] On October 22, he scored 27 points and hit the game-winning, buzzer-beating three-pointer to lift the Timberwolves to a 115–113 win over the Oklahoma City Thunder.

The last time Wiggins was inactive was November 10, 2015, when he sat out a loss to the Charlotte Hornets because of a sore right knee.

[65] On December 23, he scored 30 points and hit the go-ahead layup with 14 seconds remaining to help the Timberwolves defeat the Oklahoma City Thunder 114–112.

[69] On January 18 against the San Antonio Spurs, Wiggins passed Sam Mitchell (7,161) for second place on the franchise's career scoring list.

[72] On February 6, 2020, Wiggins and two draft picks were traded to the Golden State Warriors in exchange for Jacob Evans, D'Angelo Russell and Omari Spellman.

On March 19, 2021, Wiggins scored a season-high 40 points, alongside eight rebounds, four assists and four steals, in a 116–103 win over the Memphis Grizzlies.

[75] The Warriors qualified for the newly implemented play-in tournament; however, they suffered two straight losses to the Los Angeles Lakers and Memphis Grizzlies, failing to reach the postseason for the second straight season despite a 22-point, 10-rebound double-double from Wiggins in their loss to the Grizzlies.

[76] On December 6, 2021, Wiggins scored 28 points on a career-high eight threes made, in a 126–95 win over the Orlando Magic.

[78] He received support in the form of fan voting points from K-pop star, BamBam, who provided a strategic social media boost.

[81] In Game 4 of the NBA Finals, Wiggins posted a 17-point, 16-rebound (a playoff career high) double-double in a 107–97 win over the Boston Celtics.

[87] On December 3, Wiggins scored a season-best 36 points and matched his career high with 8-of-10 shooting from three-point range in a 120–103 win over the Houston Rockets.

[1] On August 20, 2015, Wiggins was named to the Canadian national team roster for the 2015 FIBA Americas Championship, a qualifying tournament for the 2016 Summer Olympics.

[95][96] Wiggins rejoined the team for the 2020 FIBA Men's Olympic Qualifying Tournament, averaging 21.7 points, 6.0 rebounds and 2.3 assists per game in three contests.