He claimed multiple national player of the year awards and played in the McDonald's All-American Game after his final season.

Early into his freshman season, he was suspended by the National Collegiate Athletic Association (NCAA), which deemed that Hardaway had acted as a booster by facilitating Wiseman's move to Memphis, Tennessee in 2017.

Entering his freshman season for The Ensworth School in Nashville, Tennessee, Wiseman stood 6 ft 9 in (2.06 m) and weighed 200 pounds (91 kg).

[9] On November 16, 2017, the TSSAA ruled Wiseman ineligible for his junior season because an "athletic coaching link" existed between him and Hardaway.

[17][18] Wiseman also won the Tennessee Class AAA Mr. Basketball award while appearing in the McDonald's All-American Game, the Jordan Brand Classic, and the Nike Hoop Summit.

In August 2019, a minor shoulder injury kept Wiseman from joining Memphis for a series of preseason exhibition games in Nassau, Bahamas.

[28] On November 5, Wiseman made his regular season debut with 28 points, 11 rebounds, and three blocks in 22 minutes as the Tigers defeated South Carolina State, 97–64.

[29] On November 8, Wiseman's lawyers announced that the National Collegiate Athletic Association (NCAA) ruled him ineligible to play for Memphis.

[31] On the same day, a Shelby County judge granted Wiseman a temporary restraining order against the NCAA's ruling, allowing him to keep playing.

[33] Wiseman's lawyers filed a lawsuit against the NCAA to restore his eligibility before withdrawing the case six days later in hopes of reaching an agreement.

[34] On November 20, the NCAA ruled that Wiseman would be eligible to return on January 12 after serving a 12-game suspension if he donated $11,500 to a charity of his choice.

[32][35] On December 19, 2019, after missing seven games due to suspension, Wiseman announced that he would leave Memphis, hire an agent and prepare for the 2020 NBA draft, effectively ending his college career.

[48][49] On July 10, 2022, Wiseman made his return from injury in the 2022 NBA Summer League, putting up 11 points, two rebounds, and two blocks in an 86–85 win over the San Antonio Spurs.

[57] On February 6, 2025, Wiseman was traded to the Toronto Raptors alongside cash considerations in exchange for a 2026 top 55 protected second-round pick, but was waived shortly after.