Andrews Thazhath was born on 13 December 1951 in Pudukkad, a village in the Thrissur district of what was then Travancore-Cochin (modern-day Kerala).

His early assignments included serving as Assistant Vicar in the parishes of Ollur and Lourdes Cathedral in Thrissur, where he gained respect for his pastoral care, theological knowledge, and commitment to liturgical traditions.

Additionally, he held roles in the Syro-Malabar Church's Liturgical Research Centre and the Canon Law Society of India.

During his tenure, Archbishop Thazhath has focused on strengthening the ecclesiastical structure of the Archeparchy, promoting vocations, and expanding educational and charitable initiatives.

In this role, Thazhath has been instrumental in addressing issues related to the Church’s social and educational mission in India, interfaith dialogue, and promoting communal harmony.