Andrographis paniculata, commonly known as creat or green chiretta,[2] is an annual herbaceous plant in the family Acanthaceae, native to India and Sri Lanka.

Native populations of A. paniculata are spread throughout south India and Sri Lanka which perhaps represent the center of origin and diversity of the species.

Unlike other species of the genus, A. paniculata is of common occurrence in most places in India, including the plains and hilly areas up to 500 m (1,600 ft), which accounts for its wide use.

A 2017 (pre COVID-19) meta-analysis evaluating Andrographis paniculata for acute respiratory tract infections (ARTI) indicated possible support for its efficacy and safety, but cautioned that the trials reviewed were of poor quality and thus not conclusive.

[13] Amid Thailand's COVID-19 outbreak in December 2020, the country's health ministry approved the usage of the plant extract for a pilot alternative treatment program.

[14] In July 2021, the Cabinet of Thailand approved the use of green chiretta to treat asymptomatic COVID patients after the Thai Corrections Department said the drug was beneficial in prison inmates.

[17] A 2019 review finds that A. paniculata compounds have poor solubility and relatively low potency, and that a semi-synthetic injectable derivative can cause sometimes life-threatening allergic reactions.

[18] In Cambodia the dried root macerated in alcohol is consumed as an aperitive, while the seeds make a black jelly called chahuoy khmau.