[7] Tolfenamic acid finds utility in the prevention and treatment of conditions associated with pain and inflammation.

[8][9] However, despite its efficacy when administered intramuscularly, subcutaneously, or orally,[10] TFA-based drugs have not yet gained approval in the United States and some other countries due to the significant number of reported side effects.

[14][15][16] These polymorphic forms exhibit variations in the spatial arrangement within the unit cell and in the values of the C-N(H)-C-C angle.

[16] This diversity in solid forms makes TFA an attractive candidate for modification and utilization in medical applications.

[3] Tolfenamic acid demonstrates the ability to inhibit the growth of cancer cells in the pancreas, sigmoid colon, and rectum.