Andronikos Palaiologos (son of Manuel II)

He never recovered in full, remaining in poor health for the rest of his life, eventually developing an unknown yet severe illness, possibly leprosy or gout.

When he was only eight years old his father made him a despot (despotēs) and appointed him imperial representative in Thessalonica, where he succeeded his deceased cousin John VII Palaiologos.

These negotiations resulted (although he did not have the support of the whole of the population, and was opposed by the church, which mistrusted the Latins), in a Venetian force entering the city in 1423.

The contemporary Venetian Morosini Codex mentions a conspiracy led by Andronikos to surrender Thessalonica to the Turks.

[1] According to the Greek scholar Apostolos Vakalopoulos,[2] this conspiracy may be identical to the imprisonment of four leading aristocrats, led by a certain Platyskalites, for their association with the Ottomans, as reported by the Byzantine historian Doukas.