Andronikos Palaiologos Kantakouzenos (died 4 June 1453) was the last Grand Domestic of the Byzantine Empire.
[2] His name appears on the treaty between Byzantium and Venice concluded in April 1448, in place of Demetrios Palaiologos Kantakouzenos, who was indisposed at the time.
[3] He is likely the Grand Domestic Kantakouzenos whom Emperor John VIII Palaiologos sent in the fall of 1436 to persuade the Serbians to send a delegation to the Council of Ferrara-Florence concerning the Union of Churches.
The historian Sylvester Syropoulos describes this man as the "brother-in-law of the Despot of Serbia"; Andronikos Palaiologos Kantakouzenos was the brother of Irene Kantakouzene, wife of Đurađ Branković.
[3] The Serbian church refused to participate in this council, and if the identification is correct, it could explain Andronikos' motivation for opposing marriage between Emperor Constantine and Mara Branković.