Playboy magazine founder and publisher Hugh Hefner's nickname for Little was "Little Marilyn".

Little has had roles in a number of mainstream films including Walk Hard starring John C. Reilly, American Pie: Band Camp, Rush Hour 2 and My Boss's Daughter.

She has been a guest star in episodes of TV series such as Cold Case, CSI, Nip/Tuck, Monk, The Mullets, Charmed, Malcolm in the Middle, Reno 911!

and the soap opera The Bold and the Beautiful, plus a role on the short-lived TV series Buddy Faro.

Little married actor and musician Andy Mackenzie on August 20, 2005, but later divorced him.